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affinity biologicals/Murine Fibrinogen Paired Antibody Set/MFG-EIA

  • 产品编号: MFG-EIA
  • 美  元  价: 待定
  • 市  场  价: ¥0.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: affinitybiologicals
  • 产品分类:
  • 公司分类: Paired Antibody Sets
affinity biologicals/Murine Fibrinogen Paired Antibody Set/MFG-EIA
  • affinity biologicals/Murine Fibrinogen Paired Antibody Set/MFG-EIA
商品介绍

Description

Murine Fibrinogen Paired Antibody Set

Affinity’s Murine Fibrinogen Paired Antibody Set consists of matched capture and detecting antibodies only that have been titrated and optimized for use in sandwich style ELISA assays. The product as provided contains sufficient capture and detecting antibodies for four full 96-well microplates and contains a detailed protocol sheet containing directions for use, recipes for solutions and sources for additional materials required. This Murine Fibrinogen Paired Antibody Set is intended to facilitate the end user in establishing an “in-house” immunoassay for research purposes only and must not be used for diagnostic applications.  Assay validation is the responsibility of the end user.


Product Code: MFG-EIA

Supplied Materials:
1. Capture Antibody (MFG-EIA-C): One yellow-capped vial containing 0.4 ml of polyclonal affinity purified anti-Fibrinogen antibody for coating plates.
2. Detecting Antibody (MFG-EIA-D):  One red-capped tube containing 0.4 ml of peroxidase conjugated affinity-purified polyclonal anti-Fibrinogen antibody for detection of captured Fibrinogen.
Related Products:  VisuLize Buffer Pak

Species Cross Reactivity: View Chart

Product Datasheet: Murine Fibrinogen Antigen Matched Pair Antibody Set for ELISA - MFG-EIA


Description of Fibrinogen

Most of the fibrinogen in the circulation consists of 2 copies of each chain (Aα2, Bβ2, γA2), but in normal plasma approximately 10% of the fibrinogen molecules contain one γA chain and one variant γ chain (termed γ′), in which the c-terminal AGDV residues are replaced with the amino acid sequence VRPEHPAETEYDSLYPEDDL.  This variant fibrinogen is commonly referred to as fibrinogen gamma prime (γA/γ′) but has also been called fibrinogen 2 or peak 2 fibrinogen because it elutes separately from fibrinogen 1 (γA2) by ion exchange chromatography.  Residues 414-427 of the γ′ chain of fibrin gamma prime (contain a high-affinity binding site for exosite II of thrombin, which allows the active site of bound thrombin to remain available to interact with substrates while demonstrating resistance to heparin mediated inhibition by antithrombin1-4.

References and Reviews

  1. Hantgan RR, Francis CW, Marder VJ; Fibrinogen Structure and Physiology; in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp 277-300, J.B. Lippincott Co., Philadelphia PA, USA, 1994.
  2. Binnie CG, Lord ST; The Fibrinogen Sequences that Interact with Thrombin;  Blood 81,  pp 3186-3192, 1993.
  3. Pospisil CH, Stafford AR, Fredenburgh JC, Weitz JI; Evidence that both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin; JBC 278, pp 21584-21591, 2003.
  4. Medved L, Weisel JW; Recommendations for Nomenclature on Fibrinogen and Fibrin; JTH 7, pp 355-359, 2009.

 

品牌介绍

Affinity Biologicals,Inc.是全球范围内用于血栓形成和止血研究与诊断的产品的主要制造商。我们的产品包括广泛的抗体,结合物,用于人类和动物分析物免疫测定的抗体对,完整的ELISA试剂盒的VisuLize系列以及包括VisuDep免疫缺陷因子缺乏血浆,VisuCal校准血浆的全系列人类血浆产品和VisuCon控制血浆。服务包括蛋白质纯化,抗体生产,测定开发,定制制造(包括定制冻干和能力验证材料)。


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