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affinity biologicals/Factor VIII:C Polyclonal Antibody - HRP Conjugated/SAF8C-HRP

  • 产品编号: SAF8C-HRP
  • 美  元  价: 待定
  • 市  场  价: ¥0.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: affinitybiologicals
  • 产品分类:
  • 公司分类: Product Family
affinity biologicals/Factor VIII:C Polyclonal Antibody - HRP Conjugated/SAF8C-HRP
  • affinity biologicals/Factor VIII:C Polyclonal Antibody - HRP Conjugated/SAF8C-HRP
商品介绍

Description

Factor VIII:C Polyclonal Antibody – HRP Conjugated

Affinity’s Factor VIII:C Polyclonal Antibody – HRP Conjugated is the base level of our horseradish peroxidase conjugated Factor VIII:C antibodies.  The purity of IgG is typically 90% and is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v).  The titre is essentially the same as the starting antiserum and each vial typically contains the amount of IgG recovered from one milliliter of antiserum however this IgG has been conjugated with Horseradish Peroxidase as an enzyme reporter.  This Factor VIII:C Polyclonal Antibody – HRP Conjugated is generally intended for use as labeled primary antibodies in applications such as immunoassay and immunoblotting.


Product Code: SAF8C-HRP

Retail Product Size: 0.2mg vial

Host Animal: Sheep Anti-Human Factor VIII:C Polyclonal Antibody – HRP Conjugated

Species Cross Reactivity: View Chart

Product Datasheet: Factor VIII F8 Polyclonal Antibody - hrp conjugated anti-human sheep IgG


Description of Factor VIII

Factor VIII (formerly referred to as antihemophilic globulin and Factor VIII:C) is a large glycoprotein (320 kDa) that circulates in plasma at approximately 200 ng/ml. Synthesized in the liver, the majority of Factor VIII is cleaved during expression, resulting in a heterogeneous mixture of partially cleaved forms of FVIII ranging in size from 200-280 kDa. The FVIII is stabilized by association with von Willebrand Factor to form a FVIII-vWF complex required for the normal survival of FVIII in vivo (t1/2 of 8-12 hours).

F.VIII is a pro-cofactor that is activated through limited proteolysis by thrombin. In this process F.VIIIa dissociates from vWF to combine with activated Factor IX, calcium and a phospholipid surface where it is an essential cofactor in the assembly of the Factor X activator complex. Once dissociated from vWF, FVIIIa is susceptible to inactivation by activated Protein C and by non-enzymatic decay.

Hemophilia A is a congenital bleeding disorder resulting from an X-chromosome-linked deficiency of FVIII. The severity of the deficiency generally correlates with the severity of the disease. Some Hemophiliacs (~10%) produce a FVIII protein that is partially or totally inactive. The production of neutralizing antibodies to FVIII also occurs in 5-20% of Hemophiliacs 1-3.

References and Review

  1. Lollar P, Fay PJ, Fass DN; Factor VIII and Factor VIIIa. Methods in Enzymology, 222, pg 122, 1993.
  2. Hoyer, LW, Wyshock EG, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 109-133, J.B. Lippincott Co., Philadelphia, 1994.
  3. Pittman DD, Kaufman RJ. Structure-Function Relationships of Factor VIII Elucidated through Recombinant DNA Technology. Thromb. Haemostasis. 61:161-165, 1989.
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Affinity Biologicals,Inc.是全球范围内用于血栓形成和止血研究与诊断的产品的主要制造商。我们的产品包括广泛的抗体,结合物,用于人类和动物分析物免疫测定的抗体对,完整的ELISA试剂盒的VisuLize系列以及包括VisuDep免疫缺陷因子缺乏血浆,VisuCal校准血浆的全系列人类血浆产品和VisuCon控制血浆。服务包括蛋白质纯化,抗体生产,测定开发,定制制造(包括定制冻干和能力验证材料)。


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affinity biologicals的ELISA的配对对抗体集– EIA

以下产品由匹配的捕获和检测抗体组成,可用于大多数凝血和止血相关抗原的ELISA分析的制备。产品插页提供了所需材料的配方和来源,但未提供。VisuCal抗原校准物血浆和VisuLize Buffer Pak是我们的配对对抗体套装的辅助产品,可帮助ELISA分析的制备和进行。这些产品旨在帮助最终用户建立仅用于研究目的的内部免疫测定,不得用于诊断应用。分析验证是最终用户的责任。


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