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affinity biologicals/Factor VIII:C Polyclonal Antibody - Affinity Purified - Biotinylated/SAF8C-APBIO

  • 产品编号: SAF8C-APBIO
  • 美  元  价: 待定
  • 市  场  价: ¥0.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: affinitybiologicals
  • 产品分类:
  • 公司分类: Product Family
affinity biologicals/Factor VIII:C Polyclonal Antibody - Affinity Purified - Biotinylated/SAF8C-APBIO
  • affinity biologicals/Factor VIII:C Polyclonal Antibody - Affinity Purified - Biotinylated/SAF8C-APBIO
商品介绍

Description

Factor VIII:C Polyclonal Antibody – Affinity Purified – Biotinylated

Affinity’s Factor VIII:C Polyclonal Antibody – Affinity Purified – Biotinylated is the highest level of our biotin conjugated Factor VIII:C antibodies.  During the Antigen Affinity Purification process the IgG has had any non-specific immunoglobulin fraction eliminated which enriches the specificity of the remaining immunoglobulin towards the target antigen.  The result is a very high-purity product with a substantially higher titre than whole or purified IgG.  Our Factor VIII:C Polyclonal Antibody – Affinity Purified – Biotinylated is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v) and has been conjugated with Biotin as an enzyme reporter.  This antibody is generally intended for use as labelled primary antibodies in applications such as immunoassay and immunoblotting.


Product Code: SAF8C-APBIO

Retail Product Size: 0.1mg vial

Host Animal: Sheep Anti-Human Factor VIII:C Polyclonal Antibody – Affinity Purified – Biotinylated

Species Cross Reactivity: View Chart

Product Datasheet: Factor VIII F8 Polyclonal Antibody - affinity purified Biotin conjugated anti-human sheep IgG


Description of Factor VIII

Factor VIII (formerly referred to as antihemophilic globulin and Factor VIII:C) is a large glycoprotein (320 kDa) that circulates in plasma at approximately 200 ng/ml. Synthesized in the liver, the majority of Factor VIII is cleaved during expression, resulting in a heterogeneous mixture of partially cleaved forms of FVIII ranging in size from 200-280 kDa. The FVIII is stabilized by association with von Willebrand Factor to form a FVIII-vWF complex required for the normal survival of FVIII in vivo (t1/2 of 8-12 hours).

F.VIII is a pro-cofactor that is activated through limited proteolysis by thrombin. In this process F.VIIIa dissociates from vWF to combine with activated Factor IX, calcium and a phospholipid surface where it is an essential cofactor in the assembly of the Factor X activator complex. Once dissociated from vWF, FVIIIa is susceptible to inactivation by activated Protein C and by non-enzymatic decay.

Hemophilia A is a congenital bleeding disorder resulting from an X-chromosome-linked deficiency of FVIII. The severity of the deficiency generally correlates with the severity of the disease. Some Hemophiliacs (~10%) produce a FVIII protein that is partially or totally inactive. The production of neutralizing antibodies to FVIII also occurs in 5-20% of Hemophiliacs 1-3.

References and Review

  1. Lollar P, Fay PJ, Fass DN; Factor VIII and Factor VIIIa. Methods in Enzymology, 222, pg 122, 1993.
  2. Hoyer, LW, Wyshock EG, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 109-133, J.B. Lippincott Co., Philadelphia, 1994.
  3. Pittman DD, Kaufman RJ. Structure-Function Relationships of Factor VIII Elucidated through Recombinant DNA Technology. Thromb. Haemostasis. 61:161-165, 1989.
品牌介绍

Affinity Biologicals,Inc.是全球范围内用于血栓形成和止血研究与诊断的产品的主要制造商。我们的产品包括广泛的抗体,结合物,用于人类和动物分析物免疫测定的抗体对,完整的ELISA试剂盒的VisuLize系列以及包括VisuDep免疫缺陷因子缺乏血浆,VisuCal校准血浆的全系列人类血浆产品和VisuCon控制血浆。服务包括蛋白质纯化,抗体生产,测定开发,定制制造(包括定制冻干和能力验证材料)。


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affinity biologicals凝血因子抑制剂血浆

凝血因子抑制剂血浆是通过向因子不足的血浆中添加异源中和抗体而人工产生的。中和抗体的活性通过奈梅亨-修饰的贝塞斯达抑制剂测定来确定,并且值以BU / ml报告。我们的抑制剂血浆可产生一种或多种抑制剂类别:轻度(1-10BU / ml),中度(> 10-50BU / ml)和强(> 50-200BU / ml)。尽管抑制剂血浆可以产生特定的效力,并且可以在任何体积范围内冷冻生产,但并非所有因素都具有所有效力。请查询。这些产品仅用于研究目的,不能用于诊断应用。


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