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affinity biologicals/Factor V Polyclonal Antibody - Affinity Purified - Biotinylated/SAFV-APBIO

  • 产品编号: SAFV-APBIO
  • 美  元  价: 待定
  • 市  场  价: ¥0.00
  • 品       牌:
  • 产       地: 美国(厂家直采)
  • 公       司: affinitybiologicals
  • 产品分类:
  • 公司分类: Product Family
affinity biologicals/Factor V Polyclonal Antibody - Affinity Purified - Biotinylated/SAFV-APBIO
  • affinity biologicals/Factor V Polyclonal Antibody - Affinity Purified - Biotinylated/SAFV-APBIO
商品介绍

Description

Factor V Polyclonal Antibody – Affinity Purified – Biotinylated

Affinity’s Factor V Polyclonal Antibody – Affinity Purified – Biotinylated is the highest level of our biotin conjugated Factor V antibodies.  During the Antigen Affinity Purification process the IgG has had any non-specific immunoglobulin fraction eliminated which enriches the specificity of the remaining immunoglobulin towards the target antigen.  The result is a very high-purity product with a substantially higher titre than whole or purified IgG.  Our Factor V Polyclonal Antibody – Affinity Purified – Biotinylated is provided in a solution of HEPES buffered saline containing 50% glycerol (v/v) and has been conjugated with Biotin as an enzyme reporter.  This antibody is generally intended for use as labelled primary antibodies in applications such as immunoassay and immunoblotting.


Product Code: SAFV-APBIO

Retail Product Size:  0.1mg vial

Host Animal: Sheep Anti-Human Factor V Polyclonal Antibody – Affinity Purified – Biotinylated

Species Cross Reactivity: View Chart

Product Datasheet: Factor V F5 Polyclonal Antibody - affinity purified biotin conjugated anti-human sheep IgG


Description of Factor V

Factor V (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320 kDa) that is produced in the liver.  The gene that encodes factor V (FV) is located on chromosome 1.  A congenital deficiency of FV is a hemorrhagic disorder inherited as an autosomal recessive disease.  The concentration of FV in plasma is typically 10 μg/mL.  FV is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface.  Other physiologic activators of FV include plasmin, neutrophil elastase and platelet calpain.  The activated cofactor (FVa) is an essential component of the prothrombin activator complex, which consists of FVa, activated factor X, calcium and anionic phospholipid surface.  The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone.  In a positive feedback loop, the thrombin generated accelerates its own generation by activating more FV to FVa.  Thrombin also acts to down-regulate FVa indirectly by activating Protein C, which inactivates FVa cofactor activity1-3.

References and Reviews

1. Kane WH, Davie EW; Blood Coagulation Factors V and VIII: Structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders.  Blood 71:539, 1988.

2. Hoyer, LW, Wyshock EG, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 109-133, J.B. Lippincott Co., Philadelphia, 1994.

3. Nesheim ME, Katzmann JA, Tracy PB, Mann KG; in Methods in Enzymology 80:249, 1980.

品牌介绍

Affinity Biologicals,Inc.是全球范围内用于血栓形成和止血研究与诊断的产品的主要制造商。我们的产品包括广泛的抗体,结合物,用于人类和动物分析物免疫测定的抗体对,完整的ELISA试剂盒的VisuLize系列以及包括VisuDep免疫缺陷因子缺乏血浆,VisuCal校准血浆的全系列人类血浆产品和VisuCon控制血浆。服务包括蛋白质纯化,抗体生产,测定开发,定制制造(包括定制冻干和能力验证材料)。


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affinity biologicals正常供者血浆组

VisuCon正常供体组是一组单独的正常供体血浆,可在需要时用于建立凝血测定的正常范围。正常供体血浆组包含25种单独的正常供体血浆,这些血浆已通过FDA批准的方法进行了测试,并发现HIV和肝炎呈阴性。将VisuCon正常供体组中的贫血小板血浆收集到3.2%柠檬酸盐中,双离心,并从不吸烟且无药物的典型年龄范围为18至65岁的男性和女性供体中收集。筛选VisuCon正常供体组中的所有血浆,发现FV莱顿(APCR)和狼疮抗凝剂呈阴性。测试凝血酶原时间(PT),活化的部分凝血活酶时间(APTT),


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